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ScienceScienceDaily · 18h ago

Scientists solve the mystery of a brain “switch” that can trigger weight loss in opposite ways

Activating the GIP receptor in the brainstem reduced appetite in mice, while blocking it in the hypothalamus enhanced fullness signals through different mechanisms. The finding explains why distinct obesity drugs targeting the same receptor produce similar weight loss results and suggests combining GIP treatments with GLP-1 drugs could strengthen effects.

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